Advantage II vs. Frontline


If this is the first page of the site you are reading, you may not already know that Frontline is the name of the original flea and tick control product produced by Merial and that it is no longer sold in stores since being replaced in 2000 by Frontline Plus.

Many people refer to Frontline Plus and simply call it Frontline. If you are looking for an Advantage II vs. Frontline Plus comparison discussion you can find it on our spot-on topical treatment review directory page. Please use this resource to determine the ideal flea treatment for you and your family.

If you are still curious to know the differences between Advantage II and the original Frontline, please continue reading below for a brief explanation of the differences.

The Differences between Advantage II and Frontline

The original Frontline product contained only one active ingredient called fipronil. Fipronil was effective in killing adult fleas, lice and ticks, but did not kill flea eggs. You were also only allowed to use it on puppies 8 weeks or older.

Advantage II, which can be used on puppies as young as 7 weeks, contains an insect growth regulator (IGR) called pyriproxyfen. Because insects, like fleas, change lifecyles based on decreases in the level of juvenile growth hormone in their systems, IGR’s stunt the growth and kill flea eggs and larvae by artificially increasing these hormone levels. However, Advantage II does not kill ticks.

My Recommendations

Advantage II vs. Frontline: A tie.

Even though Advantage II kills fleas in all life stages, unlike the original Frontline formula, it does not kill ticks. Personally, I find the risk posed by ticks to be far greater of a concern than the existence of flea eggs and larvae. Flea eggs and larvae are generally speaking more of a nuisance. Although Frontline lacked the ability to kill flea eggs and larvae, once they matured they would have immediately died off and the life cycle would have permanently ended anyway, albeit the flea infestation would have lasted a week or two longer.

As a side note, I do not give the Bayer products (Advantage or K9 Advantix) any bump in my ratings in light of the fact that they can be used on 7 week old puppies. This one week advantage is only important to a miniscule population of dog owners that is almost exclusively important to breeders. Since most, if not all states, have laws prohibiting the selling of puppies younger than 8 weeks, it is basically an inconsequential bonus in my judgment.