Frontline vs. Frontline Plus: What is the difference?

Many people, especially those who are looking to buy flea medication for the first time, seek out a comparison of Frontline vs. Frontline Plus. The bad news is that the quest to find the best flea treatment for dogs can be confusing. The good news is that this review will help clear up some of this confusion.

Let’s cut to the nitty-gritty.

Merial, the company that manufactures the Frontline family of products, no longer manufactures or distributes the original Frontline offering to my knowledge. Back in September of 2000, Merial introduced Frontline Plus and touted it as the “next generation in flea and tick prevention”.

So, from a practical buying decision analysis, there is really nothing to compare.

However, there is some practical use to understanding how Frontline Plus differs from Frontline so that you can see the evolution of the products in flea and tick control. It is also worth pointing out that Frontline set the bar and trend when they introduced Frontline Plus because they added a flea egg and larvae killing chemical to the formula.

This ingredient is called (S)-methoprene and it is considered an insect growth regulator. What methoprene does is keep the levels of juvenile growth hormone in flea eggs and larvae artificially high. Eggs hatch and larvae morph into fleas with decreases in juvenile growth hormones. Methoprene essentially freezes that metamorphosis causing the eggs and larvae to die.

There you have it. The only difference between Frontline and Frontline Plus are the larvicidal and ovicidal killing properties found with the addition of (S)-methoprene.

To see how Frontline stacks up with other products, please see the following reviews and comparisons of Merial’s Frontline family of products against other brands:

Frontline vs. Advantage

Frontline vs. Advantage II

Frontline vs. K9 Advantix

Frontline Plus vs. Advantage II

Frontline Plus vs. K9 Advantix II